Reaction Tips & Tricks for Organic Syntheses

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Tips.reactiontips.com news digest

  • 9 years

    Mitsunobu Reaction

    Invented by Professor Oyo Mitsunobu in 1967
    Here is a video explaining the Mechanism of Mitsunobu Reaction!
    Recently DEAD has been replaced with less harmful DIAD 

  • 10 years

    Scalable Solvent free sillylation of alcohols

    Procedure
    Charged 100g of staring alcohol (liquid or solid) to a 1L 4 neck RBF under nitogen atmosphere.
    Added 2.5 Meq. of imidazole at RT.

  • 11 years

    Esterification of a diversly functionalized molecule

    One of our colleagues has to perform an esterfication reaction to prepare ester derivative of a carboxylic acid function bearing compound. The compound has a secondary OH and N-Ac functions in addition to the carboxyl group. Use of oxalyl chloride was...

  • 12 years

    Acetonide protection in presence of acid sensitive O-Protection

    Acetonide protection in presence of acid sensitive O-protective group is very critical. You have to be very careful during this reaction. Usually acetonide protection has been carried out in presence of catalytic amount of p-TSA in acetone.
    But when you have acid sensitive protective group such as TBDMS, TBDPS etc, donot use p-TSA more than 0.001 equivalent otherwise acid sensitive protective group does not stand any more. The best procedure is the use of 2,2'-dimethoxy propane with 0....

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