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Pssrc.org news digest

  • 1 year

    Continuous melt granulation with a planetary roller granulator

    Daniel Nesgesa, Thomas Birrb, Markus Thommesa  and Jens Bartscha
    a Laboratory of Solids Process Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, Germany
    b ENTEX Rust & Mitschke GmbH, 44805 Bochum, Germany...

  • 2 years

    Is water an anti-plasticizer for amorphous lidocaine?

    by Xiaoyue Xu, Holger Grohganz and Thomas Rades from the Department of Pharmacy, University of Copenhagen
    Water is generally regarded as a universal plasticizer of amorphous drugs or amorphous drug containing systems. A decrease in glass transition temperature (Tg) is considered the general result of this plasticizing effect. A recent study however, exhibited...

  • 2 years

    Particle Engineering via QESD crystallization

    Jerome Hansen and Peter Kleinebudde
    The direct compression of powder blends into tablets can only be realized if the material has sufficient flow properties to ensure a homogeneous filling of the die during tableting. Poor flowability of an API, such as metformin hydrochloride (MF), can...

  • 2 years

    Effect of binder type and lubrication method on the binder efficacy for direct c...

    Cedrine de Backere, Valérie Vanhoorne, Chris Vervaet
    The development of direct compression (DC) formulations can remain challenging as certain active pharmaceutical ingredients show poor compactibility. Therefore, a binder can be added to the formulation to increase tablet strength, reduce tablet friability...

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Updated: October 22, 2018
Expires: November 07, 2023
Created: November 07, 2006

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