Practical Fragments
Practical Fragments Blogspot. This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding...
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Best pages on Practicalfragments.blogspot.com
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This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.
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Practical Fragments: Native mass spectrometry vs SPR
Native state electrospray ionization mass spectrometry ( ESI-MS ) is, in theory, a fast and easy way to find fragments: just mix protein wi...
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Practical Fragments: Stabilizing protein-protein interactions: part 2
Stabilizing – rather than disrupting – protein-protein interactions is increasingly popular, particularly in the context of PROTACs and mol...
Practicalfragments.blogspot.com news digest
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6 months
Detailing hot spots with atomic consensus sites
Practical Fragments haswritten frequently about hot spots, regions on proteins that are predisposed tobind ligands such as drugs. Determining whether a protein has a hot spot can helpprioritize a target for screening, and one of the more established...
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6 months
Nineteenth Annual Fragment-Based Drug Discovery Meeting
Last week the CHI Drug DiscoveryChemistry (DDC) meeting was held in San Diego. This was the largest ever, with morethan 900 participants, 95% of whom attended in person, up from 87% last year. Iwon’t attempt to cover all fourteen tracks but will just...
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7 months
Personality tests for molecules
Long-time readers of PracticalFragments will be familiar with various metrics for measuring molecules, suchas LE, LLE, and WTF. But these are all hard-edged, numerical constructs.Some folks argue that we should take a softer, more nuanced approach. This...
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7 months
Rapidly proliferating cancer cellsrequire a steady supply of nucleic acids, and cutting that off is a potentialtherapy. The enzyme dihydroorotate dehydrogenase (DHODH), which is important forpyrimidine synthesis, is thus an interesting drug target. In...
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| Web host: | Google LLC |
| Registrar: | MarkMonitor Inc. |
| Registrant: | Google LLC |
| Updated: | August 02, 2024 |
| Expires: | July 31, 2025 |
| Created: | July 31, 2000 |
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