Practical Fragments

Last year we highlighted anexample of crystallographic screening of crude reaction mixtures to findinhibitors against the oncology target PHIP(2). Of 957 molecules tested, 22showed crystallographic binding in two different orientations: 19 in a“lateral...

Transcription factors can bedifficult drug targets, particularly those whose primary structure is a “leucinezipper” in which two α-helicesgently coil around each other. Their three-dimensional structure provides fewpockets suitable for binding small...

The shape of a molecule influencesits properties. While this is true on a per-compound level, things get a littlemore controversial when discussing molecules in general. Back in 2009researchers argued that “three dimensional” molecules have better drug...

Lots of interesting events coming up this year - hope to see you at one!
February 17-19:  The Twelfth NovAliX Conference will be held for the first time in San Diego! You can read my impressions of the 2018 Boston event here, the 2017 Strasbourg event here, and Teddy's impressions of the 2013 event here, here, and here....