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We love solving hard problems from evolution and adaptive immunology. We enjoy all facets of computational biology research, from diving deeply into biological questions, to mathematical and stat...
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Introduction Pplacer places query sequences on a fixed reference phylogenetic tree according to a reference alignment. In maximum likelihood (ML) mode, pplacer tries to find the attachement location ...
Matsen.fhcrc.org news digest
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5 months
I am disturbed by the reduction of opportunities for PhD students and postdocs.The loss of funding for programs will have effects for generations of scientists.Although our research group certainly is not immune, we are financially better off than most...
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5 months
The term 'affinity maturation' understates the influence of somatic hypermutatio...
I get a little bubble of excitement every time I encounter someone who doesn’t know about antibody affinity maturation.When I do, I get to point at my neck lymph nodes and describe that there is this little Darwinian process inside you that evolves antibodies...
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8 months
The next five years are going to be amazing for learning biological processes th...
I am looking forward to a future in which AI will greatly reduce friction in designing and implementing models that directly reflect underlying biological knowledge and are directly interpretable.This can be contrasted with the “monolithic” paradigm...
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10 months
Two new approaches to learn about antibody somatic hypermutation
Somatic hypermutation (SHM) is one of the craziest things I’ve ever heard of: we have enzymes that intentionally damage and mutate our DNA!This process is the foundation of the affinity maturation process that enables us to generate high-affinity antibodies...
Domain history
| Web host: | The Fred Hutchinson Cancer Research Center |
| Registrar: | Public Interest Registry |
| Registrant: | REDACTED (Fred Hutchinson Cancer Research Center) |
| Updated: | April 14, 2024 |
| Expires: | April 14, 2034 |
| Created: | April 13, 1990 |
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