Hyperlipid

Time to look at the Vaughan mouse weight gains and actual diet compositions. Here is a recap of the weight gains:
and here is Table 1 with the percentages of energy from linoleic acid added in red by myself:
It's clear that the saturated fat group were only fed 6% of their calories as insulin sensitising linoleic acid. In addition to this relatively low amount of LA, the stearic acid in the saturates has an high F:N ratio and will in part offset the low...

Okay, back to the Vaughan paper
A High Linoleic Acid Diet does not Induce Inflammation in Mouse Liver or Adipose Tissue
and a look at their macrophages in cell culture. The pattern is consitent so I'll just run through MCP-1 gene mRNA expression. As in the last post I am going to work on the basis that these genes are, in the absence of trauma or infection, going to respond...

This paper contains a very superficial and bullet point overview of the inflammatory cascade. It omits swathes of anti inflammatory pathways and many of the boxes on the chart could be massively expanded. The paper is interested in using phytotoxins...

 Okay, time to look at this study
A High Linoleic Acid Diet does not Induce Inflammation in Mouse Liver or Adipose Tissue
It presented itself to me while I was looking  for explanations as to why linoleic acid was or wasn't inflammatory in hepatocytes. Being "inflammatory" is determined, here, by the response of treating freshly isolated cells, in this case macrophages...