eScholarship@UMassChan repository at UMass Chan Medical School
EScholarship UMass Med. eScholarship@UMassChan Repository at UMass Chan Medical School...
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eScholarship@UMassChan repository at UMass Chan Medical School
eScholarship@UMassChan Repository at UMass Chan Medical School eScholarship@UMassChan eScholarship@UMassChan is a digital repository for UMass Chan Medical School's research and scholarship, including...
Escholarship.umassmed.edu news digest
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6 years
Mutations in influenza A virus neuraminidase and hemagglutinin confer resistance...
Influenza A virus (IAV), a major cause of human morbidity and mortality, continuously evolves in response to selective pressures. Stem-directed, broadly neutralizing antibodies (sBnAbs) targeting influenza hemagglutinin (HA) are a promising therapeutic...
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6 years
HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Clas...
Retroviral proteases (PRs) have a unique specificity that allows cleavage of sites with or without a P1' proline. A P1' proline is required at the MA/CA cleavage site due to its role in a post-cleavage conformational change in the capsid protein. However...
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6 years
Structural analysis of the active site and DNA binding of human cytidine deamina...
APOBEC3s proteins (A3s), a family of human cytidine deaminases, protect the host from endogenous retro-elements and exogenous viral infections by introducing hypermutations. However, overexpressed A3s can modify genomic DNA to promote tumorigenesis,...
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6 years
Tolerating the Unwelcome Guest; How the Host Withstands Persistent Mycobacterium...
Our understanding of the host response to infections has historically focused on "resistance" mechanisms that directly control pathogen replication. However, both pathogen effectors and antimicrobial immune pathways have the capacity to damage host tissue...
Domain history
Web host: | Amazon Data Services Ireland Limited |
Registrar: | EDUCASE |
Registrant: | University of Massachusetts Worcester |
Updated: | April 04, 2024 |
Expires: | January 01, 1970 |
Created: | July 27, 1998 |
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