NanoTemper - Tools for Challenging Biophysical Characterizations

Developability profiles help you avoid risk by collecting many quality attributes associated with each candidate, enabling you to rank each candidate by the most optimal attributes and make a decision on which are worth further development.
There are many biophysical characteristics to evaluate when it comes to complex, protein-based therapeutics like biologics. Anyone working to characterize biologics will have different attributes they prioritize or different parameters they aim to optimize...

Self-association, or the tendency for a molecule to be attracted to itself, is an important assessment criterium for those concerned about how their biologic will behave in the clinic.
Researchers in early development generally use low-volume, low-concentration biologics preps for stability and quality assessment; however, once these therapeutics reach the clinic, they are generally at much higher concentrations, which alters physical...

Dynamic Light Scattering (DLS) is a versatile and simple tool used ‌for assessing the colloidal stability of drug candidates early in protein-based therapeutic development.
Like any tool or technology, when you move from theory to practice, questions arise — whether they’re about how to add the tool to a workflow, or what the experimental data tells you about your candidates....

As a discovery or early development scientist, you’re tasked with identifying the most promising biologics candidates. Your hard work during early development enables straightforward and efficient downstream process development and manufacturing phases...