Drugs Info e-Learning

Methadone Side Effects | Arrhythmia | Edema | Thrombocytopenia
Adverse effects of methadone may decrease over several weeks with prolonged administration. However, constipation and sweating may persist.
Cardiovascular: arrhythmia, bigeminal rhythms, radycardia, cardiac arrest, cardiomyopathy,...

Methadone Hypotension | CNS Depression
Methadone may also cause severe hypotension and should be used cautiously  in case of severe volume depletion or abnormal blood pressure, cardiovascular disease or dysrhythmias.
Methadone may also cause respiratory depression and care must be taken when used in patinets with respiratory disease or pre-existing respiratory conditions such as severe obesity, asthma, COPD, sleep apnea, or CNS depression. Since the respiratory effects...

Methadone Safety Issues | Contraindications | Mechanism of Action
Safety issues
Methadone is always confused with sound or look alike drugs such as dexmethylphenidate or methylphenidate.

Methadone Risk Factor | Pregnancy Category
Pregnancy Risk Factor Category: C/D (dangerous especially in prolonged used or at high doses)
Some animal studies have shown teratogenic effects, however, the data collected by Teratogen Information System are complicated by other factors including maternal use of illicit drugs, nutrition supplement, concurrent infections and psychosocial circumstances...