Ultram (Tramadol Hcl) Drug Information:

Deacreasinglifespan Blogspot. Tramadol, the common edition of Ultram, is a artificial drugs medication. The actual method of activity of tramadol is...

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Deacreasinglifespan.blogspot.com news digest

  • 12 years

    TRAMADOL PAIN TREATMENT

    Tramadol hydrochloride (Ultram, Tramal) is a centrally acting opioid analgesic, used in treating moderate to severe pain. The drug has a wide range of applications, including treatment for restless legs syndrome and fibromyalgia. It was developed by...

  • 12 years

    Detection in biological fluids

    Tramadol and O-desmethyltramadol may be quantitated in blood, plasma or serum to monitor for abuse, confirm a diagnosis of poisoning or assist in the forensic investigation of a traffic or other criminal violation or a sudden death. Most commercial opiate...

  • 12 years

    Mechanism of action

    Tramadol acts as a μ-opioid receptor agonist,[50][51]serotonin releasing agent,[3][4][52][53]norepinephrine reuptake inhibitor,[51]NMDA receptor antagonist,[54]5-HT2C receptor antagonist,[55](α7)5 nicotinic acetylcholine receptor antagonist,[56]TRPV...

  • 12 years

    Metabolism

    Tramadol undergoes hepatic metabolism via the cytochrome P450 isozyme CYP2B6, CYP2D6 and CYP3A4, being O- and N-demethylated to five different metabolites. Of these, O-desmethyltramadol is the most significant since it has 200 times the μ-affinity of...

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